leucine-rich repeat transmembrane neuronal 2 protein; leucine-rich repeat neuronal 2 protein (KIAA0416, LRRTM2)

Function

• role in the development & maintenance of excitatory synapse in the vertebrate nervous system
• regulates surface expression of AMPA receptors
• acts as a ligand for the presynaptic receptors NRXN1-A & NRXN1-B (putative)
• interacts with DLG4 & NRXN1 (putative)

Structure

• synaptogenic effects are mediated by the extracellular LRR region (putative)
• belongs to the LRRTM family
• contains 10 LRR repeats (leucine-rich repeats)
• contains 1 LRRCT domain
• contains 1 LRRNT domain

Compartment

• cell membrane
• cell junction, synapse, postsynaptic cell membrane
• single-pass type 1 membrane protein (putative)
• localized to excitatory synapses (putative)

Expression

• expressed in neuronal tissues

Notes

• appears to be same as leucine-rich repeat neuronal protein 2

More general terms

• membrane protein
• glycoprotein

Additional terms

• leucine-rich repeat neuronal protein 2; leucine-rich repeat neuronal protein 5; glioma amplified on chromosome 1 protein (LRRN2, GAC1, LRRN5, UNQ256/PRO293)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=26045
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:26045
• OMIM: https://mirror.omim.org/entry/610868
• UniProt: http://www.uniprot.org/uniprot/O43300.html