neurexin-1-alpha; neurexin I-alpha (NRXN1, KIAA0578)
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Function
- neuronal cell surface protein
- may be involved in cell recognition & cell adhesion
- may mediate intracellular signaling
- specific isoforms bind to alpha-dystroglycan & to alpha-latroxin
- cytoplasmic C-terminal region binds to CASK, CASKIN1 & APBA1
- interacts with SYT13 & SYTL1 (putative)
Structure
- N-glycosylated & O-glycosylated (putative)
- the laminin G-like domain 2 binds to NXPH1
- belongs to the neurexin family
- contains 3 EGF-like domains
- contains 6 laminin G-like domains
Compartment
membrane Alternative promoter: yes
Alternative splicing
named isoforms=2
Expression
- heart & brain
- expressed in all brain regions
- highest levels in the claustrum & thalamic nuclei[3]
More general terms
References
- ↑ Ushkaryov YA et al Neurexins: synaptic cell surface proteins related to the alpha-latrotoxin receptor and laminin. Science 257:50 1992 PMID: https://www.ncbi.nlm.nih.gov/pubmed/1621094
- ↑ Hata Y et al Interaction of synaptotagmin with the cytoplasmic domains of neurexins. Neuron 10:307 1993 PMID: https://www.ncbi.nlm.nih.gov/pubmed/8439414
- ↑ 3.0 3.1 Ullrich B et al Cartography of neurexins: more than 1000 isoforms generated by alternative splicing and expressed in distinct subsets of neurons. Neuron 14:497 1995 PMID: https://www.ncbi.nlm.nih.gov/pubmed/7695896
- ↑ UniProt http://www.uniprot.org/uniprot/Q9ULB1.html