synaptotagmin-like protein 1; exophilin-7; protein JFC1 (SYTL1, SLP1, SB146)

Function

• role in vesicle trafficking
• binds PI(3,4,5)triphosphate, NRXN1, RAB27A (GTPactivated), NCF2
• acts as a RAB27A effector protein
  • binds RAB27A (GTP-bound) via its N-terminus (putative)
• may play a role in cytotoxic granule exocytosis in lymphocytes

Structure

• contains 2 C2 domains
• contains 1 RabBD (Rab-binding) domain

Compartment

peripheral membrane protein (cytoplasmic side)

Alternative splicing

named isoforms=2

Expression

• expressed in bone marrow, lymphoid tissues > cerebellum, occipital lobe, prostate, stomach, kidney, appendix, lung, trachea

More general terms

• synaptotagmin-like protein (SYTL)
• exophilin
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=84958
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:84958
• OMIM: https://mirror.omim.org/entry/608042
• UniProt: http://www.uniprot.org/uniprot/Q8IYJ3.html