leucine-rich repeat neuronal protein 2; leucine-rich repeat neuronal protein 5; glioma amplified on chromosome 1 protein (LRRN2, GAC1, LRRN5, UNQ256/PRO293)

Structure

• contains 1 Ig-like C2-type domain (immunoglobulin-like)
• contains 11 LRR repeats (leucine-rich repeats)

Compartment

• membrane; single-pass type 1 membrane protein (putative)
• overamplified in malignant gliomas

Expression

• brain, adult - high levels
• heart & kidney, adult - lower levels

Pathology

over-amplified in malignant gliomas

More general terms

• leucine-rich repeat-containing protein (LRRC)
• glycoprotein
• membrane protein

Additional terms

• leucine-rich repeat & immunoglobulin-like domain-containing nogo receptor-interacting protein 3; leucine-rich repeat neuronal protein 6B; leucine-rich repeat neuronal protein 2 (LINGO3, LERN2, LRRN6B)
• leucine-rich repeat transmembrane neuronal 2 protein; leucine-rich repeat neuronal 2 protein (KIAA0416, LRRTM2)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10446
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10446
• OMIM: https://mirror.omim.org/entry/605492
• UniProt: http://www.uniprot.org/uniprot/O75325.html