transthyretin (prealbumin) in serum/plasma
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Reference interval
- 20-36 mg/dL
Clinical significance
- used as marker for nutritional assessment*
- low levels associated with malnutrition
- low levels also associated with inflammatory state
- 1/2life is 48 hours, thus changes in serum levels respond faster to successful intervention than serum albumin (1/2life of 18-20 days)[4]
- levels respond faster than serum albumin to nutrition reconstitution
* not sufficiently sensitive or specific to determine adequacy of nutrient intake[4]
Decreases
More general terms
Additional terms
Component of
References
- ↑ Interpretation of Diagnostic tests, 8th edition, Wallach J, Lippincott, Williams & Wilkens, Philadelphia, 2007, pg 15
- ↑ Prealbumin Laboratory Test Directory ARUP: http://www.aruplab.com/guides/ug/tests/0050435.jsp
- ↑ Shenkin A Serum prealbumin: Is it a marker of nutritional status or of risk of malnutrition? Clin Chem. 2006 Dec;52(12):2177-9. PMID: https://www.ncbi.nlm.nih.gov/pubmed/17138848
- ↑ 4.0 4.1 4.2 Geriatric Review Syllabus, 8th edition (GRS8) Durso SC and Sullivan GN (eds) American Geriatrics Society, 2013
Geriatric Review Syllabus, 9th edition (GRS9) Medinal-Walpole A, Pacala JT, Porter JF (eds) American Geriatrics Society, 2016