WAS protein family homolog; protein FAM39DP (WASH)

Function

• presumbly cytoskeletal proteins
• components of WASH complex

Genetics

• WASH genes duplicated to multiple chromosomal ends during primate evolution, with highest copy number reached in humans, whose WASH repertoires probably vary extensively among individuals
• it is therefore difficult to determine which gene is functional or not
• the telomeric region of chromosome 9p is paralogous to the pericentromeric regions of chromosome 9 as well as to 2q
• paralogous regions contain 7 transcriptional units
• duplicated WASH genes are also present in the Xq/Yq pseudoautosomal region, as well as on chromosome 1 & chromosome 15
• the chromosome 16 copy seems to be a pseudogene

More general terms

• cytoskeletal protein
• evolutionary divergent human protein

More specific terms

• WAS protein family homolog 1; protein FAM39E; CXYorf1-like protein on chromosome 9 (WASH1, FAM39E)
• WAS protein family homolog 3; protein FAM39DP (WASH3P, FAM39DP)
• WAS protein family homolog 4; protein FAM39CP (WASH4P FAM39CP)
• WAS protein family homolog 6; protein FAM39A (WASH6P, CXYorf1, FAM39A)