WAS protein family homolog 6; protein FAM39A (WASH6P, CXYorf1, FAM39A)

Function

• acts as a nucleation-promoting factor at the surface of endosomes
• recruits & activates the Arp2/3 complex to induce actin polymerization
• role in fission of tubules that serve as transport intermediates during endosome sorting
• component of the WASH complex
• interacts (via WHD1 region) with FAM21C

Structure

• belongs to the WASH1 family
• contains 1 WH2 domain

Compartment

• early endosome membrane
• recycling endosome membrane
• localization to the endodome membrane is mediated via its interaction with FAM21

Alternative splicing

named isoforms=2

Genetics

• WASH genes duplicated to multiple chromosomal ends during primate evolution, with highest copy number reached in humans, whose WASH repertoires probably vary extensively among individuals
• the gene encoding for this protein is located in the pseudoautosomal region 2 (PAR2) of X & Y chromosomes

More general terms

• WAS protein family homolog; protein FAM39DP (WASH)

Component of

• WASH complex

Database

• UniProt: http://www.uniprot.org/uniprot/Q9NQA3.html