WAS protein family homolog 3; protein FAM39DP (WASH3P, FAM39DP)
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Function
- acts as a nucleation-promoting factor at the surface of endosomes, where it recruits & activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting (putative)
- component of the WASH complex
- interacts (via WHD1 region) with FAM21C
Structure
- belongs to the WASH1 family
- contains 1 WH2 domain
Compartment
- early endosome membrane (putative)
- recycling endosome membrane (putative)
- localization to the endodome membrane is mediated via its interaction with FAM21
Genetics
- WASH genes duplicated to multiple chromosomal ends during primate evolution, with highest copy number reached in humans, whose WASH repertoires probably vary extensively among individuals[2]
- it is therefore difficult to determine which gene is functional or not
- the telomeric region of chromosome 9p is paralogous to the pericentromeric regions of chromosome 9 as well as to 2q
- paralogous regions contain 7 transcriptional units
- duplicated WASH genes are also present in the Xq/Yq pseudoautosomal region, as well as on chromosome 1 & chromosome 15
- the chromosome 16 copy seems to be a pseudogene
More general terms
Component of
References
- ↑ UniProt http://www.uniprot.org/uniprot/C4AMC7.html
- ↑ 2.0 2.1 Linardopoulou EV et al Human subtelomeric WASH genes encode a new subclass of the WASP family. PLoS Genet. 2007 Dec;3(12):e237. PMID: https://www.ncbi.nlm.nih.gov/pubmed/18159949