teratocarcinoma-derived growth factor 1; cripto-1 growth factor; CRGF; EGF-like cripto protein CR1 (TDGF1, CRIPTO)

Function

• could play a role in the determination of epiblastic cells that subsequently give rise to the mesoderm
• interacts with the activin type-1 receptor ACVR1B

Structure

contains 1 EGF-like domain

Compartment

cell membrane; lipid-anchor, GPI-anchor

Expression

• preferentially expressed in gastric carcinomas & colorectal carcinomas than in their normal counterparts
• expressed in breast & lung

More general terms

• glypiated protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6997
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6997
• OMIM: https://mirror.omim.org/entry/187395
• UniProt: http://www.uniprot.org/uniprot/P13385.html