scleromyxedema; lichen myxedematosus; papular mucinosis

Etiology

• association with monoclonal gammopathy, paraproteinemia
  • generally IgG lambda
  • multiple myeloma
  • AL amyloidosis

Epidemiology

• more common in men than women

Pathology

• skin biopsy
  • mucin deposition
  • stellate fibrobasts in dermis (fibroblast proliferation)
  • collagen deposition
• involves
  • nervous system
  • gastrointestinal system
  • cardiovascular system

* histopathology images

Clinical manifestations

• waxy, yellow-red papules over thickened skin (induration) of face, upper trunk, neck & arms

* images

Laboratory

• see monoclonal gammopathy
  • serum protein electrophoresis
  • urine protein electrophoresis
  • immunofixation electrophoresis shows IgG lambda
• skin biopsy

More general terms

• skin disease (dermatologic disorder, dermatopathy, dermatosis)
• sclerosis

Additional terms

• myxedema; thyroid dermopathy (includes myxedema coma)
• scleredema (Buschke disease)
• scleroderma (diffuse cutaneous systemic sclerosis)