extra-articular manifestations of rheumatoid arthritis

Clinical manifestations

• dermatologic
  • rheumatoid nodules
  • vasculutis
  • drug reactions
• ophthalmologic
  • keratoconjunctivitis sicca
  • episcleritis, scleritis, scleromalacia perforans
• pulmonary
  • pulmonary fibrosis, basilar
  • lung nodules, multiple
  • pleuritis
  • bronchiolitis obliterans
• cardiac
  • pericarditis, pericardial effusion
  • cardiac valvular defects
  • cardiac conduction system defects
  • coronary artery disease
• gastrointestinal
  • xerostomia
  • gastritis or peptic ulcer disease from NSAIDs
• renal
  • proteinuria if secondary amyloid is present
  • interstitial nephritis from NSAIDs or other agents
• hepatic
  • nodular regenerative hyperplasia
  • portal fibrosis
• neurologic
  • cervical spine instability
  • peripheral nerve entrapment
  • mononeuritis multiplex from vasculitis
• hematologic
  • lymphadenopathy
  • splenomegaly
  • leukopenia (Felty syndrome)
  • malignancy
  • amyloidosis
  • cryogglobulinemia
  • large granular lymphocyte syndrome

Additional terms

• rheumatoid arthritis (RA)