canstatin

Introduction

cleavage product corresponding to the collagen 4 alpha-2 NC1 domain

Function

• has both anti-angiogenic & anti-tumor cell activity
• inhibits proliferation & migration of endothelial cells,
• reduces mitochondrial membrane potential
• induces apoptosis
  • specifically induces Fas-dependent apoptosis
  • activates procaspase-8 & procaspase-9 activity

More general terms

• collagen 4 alpha-2; contains: canstatin (COL4A2)