peritoneal carcinomatosis
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Etiology
- ovarian cancer
- women with peritoneal carcinomatosis of unknown primary have ovarian cancer until proven otherwise
- salpingo-oophorectomy reduces risk of cancer in patients with BRCA1 mutations; however, peritoneal carcinoma histologically indistinguishable from ovarian cancer may develop
Genetics
- associated with BRCA1 mutations
Clinical manifestations
Laboratory
- in patients with ovarian cancer or unknown primary, serum CA125 can be useful in monitoring response to therapy
Management
- if no primary neoplasm is identified, treat women as if they have stage III ovarian cancer
- surgical debulking including salpingo-oophorectomy, hysterectomy, omentectomy, appendectomy, lymphadenectomy followed by chemotherapy[1]
- prognosis: 5 year survival is 15-20%[1]
More general terms
References
- ↑ 1.0 1.1 1.2 1.3 Medical Knowledge Self Assessment Program (MKSAP) 14,16.17 American College of Physicians, Philadelphia 2006,2012, 2015
- ↑ Muggia FM, Baranda J. Management of peritoneal carcinomatosis of unknown primary tumor site. Semin Oncol. 1993 Jun;20(3):268-72. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8503022