graft-versus-leukemia (GVL)

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Introduction

effect mediated via donor T cells & natural killer cells effective in eliminating residual host acute myeloid leukemia (AML) cells after allogeneic stem-cell transplantation

Pathology

More general terms

References

  1. 1.0 1.1 Vago L et al Loss of mismatched HLA in leukemia after stem-cell transplantation. N Engl J Med 2009 Jul 30; 361:478 PMID: https://www.ncbi.nlm.nih.gov/pubmed/19641204
    Barrett J and Blazar BR. Genetic trickery - Escape of leukemia from immune attack. N Engl J Med 2009 Jul 30; 361:524. PMID: https://www.ncbi.nlm.nih.gov/pubmed/19641211