animal toxicity of memantine

Introduction

Rats fed memantine* for 14 days sustained no adverse neuronal effects.

* 6X the maximum recommended dose for humans on a mg/m2 basis

In rats, memantine induces lesions similar to those observed with other NMDA receptor antagonists.

• vacuolation & necrosis in multipolar neurons & pyramidal neurons in layers 3 & 4 of the posterior cingulate cortex & retrosplenial cortex

These lesions may be seen after a single dose of memantine.

More general terms

• property