ingenol mebutate (Picato)
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Introduction
diterpene ester extracted & purified from the plant Euphorbia peplus
Indications
Contraindications
- do not use near lips or eyes
Dosage
- apply daily for 3 days*
- use to treat one area of skin at a time,
- treated area should be < 25 cm2[3]
- use ingenol disoxate for treatment of larger areas
- a new tube should be used for each treatment day
Gel: 0.015%, 0.025%, 0.05%
* wash handsthoroughly with soap & water immediately use to avoid accidental transfer[3]
Adverse effects
- transient local skin responses consisting primarily of erythema, flaking/scaling, & crusting
- reports of severe allergic reactions[3]
- severe eye injuries & skin reactions[3]
- reports of Herpes zoster (shingles)[3]
- no evidence of treatment-related scarring
Mechanism of action
- localized induction of necrosis followed by a transient inflammatory response
More general terms
Additional terms
References
- ↑ Anderson L et al Randomized, double-blind, double-dummy, vehicle-controlled study of ingenol mebutate gel 0.025% and 0.05% for actinic keratosis. J Am Acad Dermatol 2009 Jun; 60:934. PMID: https://www.ncbi.nlm.nih.gov/pubmed/19467365
- ↑ Prescriber's Letter 19(3): 2012 Actinic Keratoses Treatments Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=280306&pb=PRL (subscription needed) http://www.prescribersletter.com
- ↑ 3.0 3.1 3.2 3.3 3.4 3.5 FDA Safety Alert. 08/21/2015 Picato (ingenol mebutate) Gel: Drug Safety Communication - FDA Warns of Severe Adverse Events, Requires Label Changes. http://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm459311.htm