alpha-1 antitrypsin in serum/plasma (AAT)
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Indications
- evaluation of hereditary alpha-1 antitrypsin deficiency
- early onset emphysema
- evaluation of persistent hyperbilirubinemia or jaundice
Reference interval
* using cutoff < 85 mg/dL for alpha-1 antitrypsin deficiency
- PiZZ phenotype: sensitivity of 99.5%, specificity of 96.5%
- PiSZ phenotype: sensitivity of 85.9%[5]
Increases
- inflammation
- surgery, trauma
- pregnancy, estrogens, oral contraceptive
Decreases
- nephrotic syndrome
- terminal hepatic disease or pancreatic disease
- hereditary alpha-1 antitrypsin deficiency
Specimen
Procedure
More general terms
More specific terms
- alpha-1 antitrypsin MM in serum
- alpha-1 antitrypsin MS in serum
- alpha-1 antitrypsin MZ in serum
- alpha-1 antitrypsin SS in serum
- alpha-1 antitrypsin SZ in serum
- alpha-1 antitrypsin ZZ in serum
Additional terms
- alpha-1 antitrypsin deficiency
- alpha-1-antitrypsin; alpha-1 protease inhibitor; alpha-1-antiproteinase; Serpin A1 (SERPINA1, AAT, PI, PRO0684, PRO2209)
- SERPINA1 gene mutation; alpha-1 antitrypsin gene mutation
References
- ↑ Clinical Guide to Laboratory Tests, 3rd edition, NW Tietz ed, WB Saunders, Philadelphia, 1995
- ↑ Alpha-1-Antitrypsin Laboratory Test Directory ARUP: http://www.aruplab.com/guides/ug/tests/0050001.jsp
- ↑ Panel of 5 tests Laboratory Test Directory ARUP: http://www.aruplab.com/guides/ug/tests/0051256.jsp
- ↑ Mini Panel of 2 tests: Alpha-1-Antitrypsin . A1A Phenotype Laboratory Test Directory ARUP: http://www.aruplab.com/guides/ug/tests/0080500.jsp
- ↑ 5.0 5.1 5.2 Hurley K, O'Connor GT Serum alpha1-Antitrypsin Concentration in the Diagnosis of alpha1-Antitrypsin Deficiency. JAMA. 2018;319(19):2034-2035. May 15, 2018 PMID: https://www.ncbi.nlm.nih.gov/pubmed/29800192 https://jamanetwork.com/journals/jama/fullarticle/2681172