2A zinc finger protein; zinc finger E-box-binding homeobox 1; transcription factor 8; negative regulator of IL2 (ZEB1, TCF8, AREB6)

Function

• inhibits interleukin-2 (IL-2) gene expression
• may be responsible for transcriptional repression of the IL-2 gene
• enhances or represses promoter activity of the ATP1A1 gene depending on cell type

Structure

• belongs to the delta-EF1/ZFH-1 C2H2-type Zn+2-finger family
• contains 7 C2H2-type Zn+2 fingers
• contains 1 homeobox DNA-binding domain

Compartment

nucleus

Expression

• expressed in heart & skeletal muscle
• not expressed in liver, spleen, or pancreas

Pathology

• defects in ZEB1 are the cause of posterior polymorphous corneal dystrophy type 3

More general terms

• homeobox protein
• C2H2 type zinc finger protein
• transcription factor (TF)

Database

• UniProt: http://www.uniprot.org/uniprot/P37275.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6935
• OMIM: https://mirror.omim.org/entry/189909