pseudothrombocytopenia
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Introduction
Diminished electronic platelet counts resulting from platelet aggregation or platelet clumping in vitro.
Etiology
- occurs most frequently in specimens collected with EDTA, less often with heparin, when allowed to stand prior to analysis
- platelets may clump or aggregate around leukocytes
- phenomenon is thought to be due to antibodies causing platelets to aggregate in vitro, but not in vivo
Laboratory
- platelet counts as low as 10,000/uL[4]
- diagnosis is made by examination of the peripheral smear for platelet aggregates
- repeat platelet count using citrate as the anticoagulant[1][3]
More general terms
Additional terms
References
- ↑ 1.0 1.1 Medical Knowledge Self Assessment Program (MKSAP) 11, 15, 16, 17. American College of Physicians, Philadelphia 1998, 2009, 2012, 2015
- ↑ Froom P, Barak M. Prevalence and course of pseudothrombocytopenia in outpatients. Clin Chem Lab Med. 2011 Jan;49(1):111-4. PMID: https://www.ncbi.nlm.nih.gov/pubmed/20961195
- ↑ 3.0 3.1 Lippi G, Plebani M. EDTA-dependent pseudothrombocytopenia: further insights and recommendations for prevention of a clinically threatening artifact. Clin Chem Lab Med. 2012 Aug;50(8):1281-5. PMID: https://www.ncbi.nlm.nih.gov/pubmed/22868791
- ↑ 4.0 4.1 NEJM Knowledge+ Hematology
Lardinois B, Favresse J, Chatelain B, Lippi G, Mullier F. Pseudothrombocytopenia-A Review on Causes, Occurrence and Clinical Implications. J Clin Med. 2021 Feb 4;10(4):594. PMID: https://www.ncbi.nlm.nih.gov/pubmed/33557431 PMCID: PMC7915523 Free PMC article. Review.