zinc finger CCCH domain-containing protein 12D; MCP-induced protein 4; p34 (ZC3H12D, MCPIP4)

Function

putative tumor suppressor

Structure

• belongs to the ZC3H12 family
• contains 1 C3H1-type Zn+2 finger

Alternative splicing

named isoforms=3

Expression

• induced by prolonged exposure to lipopolysaccharide (LPS) in acute monocytic leukemia cell line THP-1 cells

Pathology

• chromosomal translocation t(2;6)(p12;q25) involving ZC3H12D with IGK may be the cause of the transformation of follicular lymphoma (FL) to diffuse large B-cell lymphoma
• resulting protein may not be expressed

More general terms

• zinc finger protein
• anti-oncoprotein (tumor suppressor protein)

Database

• OMIM: https://mirror.omim.org/entry/611106
• UniProt: http://www.uniprot.org/uniprot/A2A288.html