homeobox protein HMX3 (homeobox protein H6 family member 3, homeobox protein Nkx-5.1, HMX3 NKX-51, NKX5-1)

Function

• transcription factor involved in specification of neuronal cell types
• required for inner ear & hypothalamus development
• binds to the 5'-CAAGTG-3' core sequence
• controls semicircular canal formation in the inner ear
• also required for hypothalamic/pituitary axis of the CNS

Structure

• belongs to the HMX homeobox family
• contains 1 homeobox DNA-binding domain

Compartment

nucleus (putative)

More general terms

• homeobox protein
• transcription factor (TF)

Database

• UniProt: http://www.uniprot.org/uniprot/A6NHT5.html