RNA-binding motif protein, Y chromosome, family 1 member B (RBMY1B)

Function

• RNA-binding protein
• may be involved in spermatogenesis
• required for sperm development, possibly via role in pre-mRNA splicing in the testis
• interacts with splicing factor proteins SFRS3/SRP20, SFRS10, KHDRBS1/SAM68 & KHDRBS3

Structure

contains 1 RRM domain (RNA recognition motif)

Compartment

nucleus

Expression

• testis-specific
• expressed in all of the transcriptionally active stages of germ cell development from spermatogonia through spermatocytes to round spermatids

Genetics

• the RBMY1 proteins are encoded by strongly repeated regions of the Y chromosome, mostly within the AZFb region
• the exact number of functional copies is unclear & may vary between individuals, & some of them may represent pseudogenes
• the proteins are very similar, which makes their indidual characterization difficult
• thus, most experiments do not discriminate between the different members
• reported interactions with a RBMY1 protein likely involve all the proteins

More general terms

• nuclear protein
• RNA-binding protein
• testis-specific protein

Database

• UniProt: http://www.uniprot.org/uniprot/A6NDE4.html