inhibitor of nuclear factor kappa-B kinase-interacting protein; I kappa-B kinase interacting protein; IKK-interacting protein (IKIP, IKBIP)

Function

• target of TP53/p53 with pro-apoptotic function
• isoform 4 may be phosphorylated at Thr-362 by similarity with mouse isoform 1 (Ikip1)
• N-glycosylated
• isoform 4 is glycosylated at Asn-154

Compartment

• endoplasmic reticulum membrane
• isoform 4 deletion of the hydrophobic, or transmembrane region between AA 45-63 results in uniform distribution throughout the cell, suggesting that this region is responsible for endoplasmic reticulum localization

Alternative splicing

named isoforms=4

Expression

• expressed in vein endothelial cells
• isoform 4 is expressed in lung, kidney, spleen, thymus & skeletal muscle
• induced by X-irradiation

Genetics

• IKIP gene shares a common promoter with APAF1 from which the 2 genes are transcribed in the opposite direction

Notes

variant in position: 122:Q->H (in dbSNP:rs12322444)

More general terms

• glycoprotein
• membrane protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q70UQ0.html