Rhomboid family member 1 (p100hRho, Rhomboid 5 homolog 1, RHBDF1, C16orf8)

Function

• not expected to have protease activity
• N-glycosylated

Structure

• homodimer, or homooligomer
• interacts with TGFA & HBEGF
• belongs to the peptidase S54 family
• lacks the conserved Ser in position 720 essential for serine protease activity; enzyme activity is thus unlikely

Compartment

• endoplasmic reticulum membrane
• Golgi apparatus membrane
• predominantly localized in the endoplasmic reticulum membrane

Expression

• highly expressed in heart, skeletal muscle, placenta & pancreatic islet
• detected at lower levels in colon, kidney, small intestine & lung

More general terms

• glycoprotein
• transmembrane 7c protein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6428
• UniProt: http://www.uniprot.org/uniprot/Q96CC6.html