annexin A2-like protein; annexin A2 pseudogene 2; lipocortin II pseudogene (ANXA2P2, ANX2L2, ANX2P2, LPC2B)
Jump to navigation
Jump to search
Function
- Ca+2-regulated membrane-binding protein whose affinity for Ca+2 is greatly enhanced by anionic phospholipids (putative)
- binds two Ca+2 with high affinity
- may be involved in heat-stress response
- may cross-link plasma membrane phospholipids with actin & the cytoskeleton & be involved with exocytosis
Structure
- pair of annexin repeats may form one binding site for Ca+2 & phospholipid (putative)
- heterotetramer containing 2 light chains of S100A10/p11 & 2 heavy chains of ANXA2P2/p36 (putative)
- belongs to the annexin family
- contains 4 annexin repeats
Compartment
- secreted, extracellular space, extracellular matrix, basement membrane (putative)
- melanosome
- in the lamina beneath the plasma membrane
- in melanosome fractions from stage I to stage IV
- translocated from the cytoplasm to the cell surface through a Golgi-independent mechanism (putative)
Notes
could be the product of a pseudogene