histone-lysine N-methyltransferase MLL5 (myeloid/lymphoid or mixed-lineage leukemia protein 5, lysine N-methyltransferase 2E, MLL5, KMT2E)

Function

• histone methyltransferase
• probably methylates Lys-4 of histone H3
• histone H3 Lys-4 methylation represents a specific tag for epigenetic transcriptional activation (putative)
• overexpression inhibits cell cycle progression

S-adenosyl-L-methionine + histone L-lysine <--> S-adenosyl-L-homocysteine + histone N(6)-methyl-L-lysine

Structure

• belongs to the histone-lysine methyltransferase family, TRX/MLL subfamily
• contains 1 PHD-type Zn+2 finger
• contains 1 SET domain

Compartment

• nucleus speckle
• absent from the nucleolus

Alternative splicing

named isoforms=7

Expression

• widely expressed in both adult & fetal tissues
• highest levels of expression observed in fetal thymus & kidney & in adult hematopoietic tissues, jejunum & cerebellum

More general terms

• histone N-methyltransferase
• zinc finger protein
• phosphoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5590
• OMIM: https://mirror.omim.org/entry/608444
• UniProt: http://www.uniprot.org/uniprot/Q8IZD2.html