hyperleucinemia; leucinosis
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Laboratory
- increased leucine in serum/plasma
Comparative biology
- mouse models with hyperleucinemia display hippocampus-selective retromer deficiency
* retromer-dependent trafficking is implicated in the pathogenesis of Alzheimer's disease
- 2 key retromer proteins, VPS35 & VPS26, are deficient in the hippocampal formation of patients with Alzheimer's disease[1]
More general terms
Additional terms
References
- ↑ 1.0 1.1 Morabito MV, Berman DE, Schneider RT et al Hyperleucinemia causes hippocampal retromer deficiency linking diabetes to Alzheimer's disease. Neurobiol Dis. 2014 May;65:188-92. Epub 2014 Jan 14. PMID: https://www.ncbi.nlm.nih.gov/pubmed/24440570 Free PMC Article