hyperleucinemia; leucinosis

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^[1]

Laboratory

increased leucine in serum/plasma

Comparative biology

mouse models with hyperleucinemia display hippocampus-selective retromer deficiency

* retromer-dependent trafficking is implicated in the pathogenesis of Alzheimer's disease

2 key retromer proteins, VPS35 & VPS26, are deficient in the hippocampal formation of patients with Alzheimer's disease^[1]

More general terms

metabolic disease

Additional terms

leucine

References

↑ ^{Jump up to: 1.0} ^1.1 Morabito MV, Berman DE, Schneider RT et al Hyperleucinemia causes hippocampal retromer deficiency linking diabetes to Alzheimer's disease. Neurobiol Dis. 2014 May;65:188-92. Epub 2014 Jan 14. PMID: https://www.ncbi.nlm.nih.gov/pubmed/24440570 Free PMC Article

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