influenza A H5N1 virus
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Epidemiology
- virus jumped from poultry to humans in Hong Kong 1997
- airborne transmistion among ferrets[2]
- pandemic variant of H5N1 could develop[2]
- 2015 bird flu epidemic circulating among U.S. poultry[3]
Pathology
- etiologic agent of avian flu
- the virus is immune to the antiviral effects of interferons & tumor necrosis factor alpha
Genetics
- Fatal flu virus resulting from point mutation in NS1 gene.
Laboratory
- rRT-PCR Swine Flu Panel
- influenza virus A serology
- influenza virus A H5 RNA
- influenza virus A H5 antigen
- influenza virus identified by culture
Complications
- high mortality (> 50%)[1]
Management
- H5N1 vaccine FDA-approved Nov 2013
- millions of chickens & turkeys were killed to stop spread of the virus
- infected patients were isolate
More general terms
Additional terms
References
- ↑ 1.0 1.1 Physician's First Watch, April 25, 2013 David G. Fairchild, MD, MPH, Editor-in-Chief Massachusetts Medical Society http://www.jwatch.org
- ↑ 2.0 2.1 2.2 Zhang Y et al. H5N1 hybrid viruses bearing 2009/H1N1 virus genes transmit in guinea pigs by respiratory droplet. Science 2013 Jun 21; 340:1459 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/23641061 <Internet> http://www.sciencemag.org/content/340/6139/1459
- ↑ 3.0 3.1 3.2 Centers for Disease Control and Prevention (CDC) Emergency Preparedness and Response. June 2, 2015 Bird Infections with Highly-Pathogenic Avian Influenza A (H5N2), (H5N8), and (H5N1) Viruses: Recommendations for Human Health Investigations and Response. http://emergency.cdc.gov/han/han00378.asp
- ↑ Journal Watch 22(20):149, 2002
Seo SH et al Lethal H5N1 influenza viruses escape host anti-viral cytokine responses. Nat Med 8:950, 2002 PMID: https://www.ncbi.nlm.nih.gov/pubmed/12195436 - ↑ Herfst S et al. Airborne transmission of influenza A/H5N1 virus between ferrets. Science 2012 Jun 22; 336:1534. PMID: https://www.ncbi.nlm.nih.gov/pubmed/22723413
Imai M et al. Experimental adaptation of an influenza H5 HA confers respiratory droplet transmission to a reassortant H5 HA/H1N1 virus in ferrets. Nature 2012 Jun 21; 486:420 PMID: https://www.ncbi.nlm.nih.gov/pubmed/22722205 - ↑ Centers for Disease Control and Prevention (CDC) http://www.cdc.gov/flu/avian/
- ↑ Key Facts About Avian Influenza (Bird Flu) & Avian Influenza A (H5N1) Virus http://www.cdc.gov/flu/avian/gen-info/facts.htm