H5N1 influenza vaccine; avian flu vaccine (Audenz)

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Indications

monovalent adjuvanted vaccine for the prevention of H5N1 influenza (FDA-approved Nov 2013)

1st vaccine 2006
12-fold higher dose than standard influenza vaccine required for protective activity

↑ Trenor JJ et al, Safety and immunogenicity of an inactivated subvirion influenza A (H5N1) vaccine N Engl J Med 2006; 354:1343 PMID: https://www.ncbi.nlm.nih.gov/pubmed/16571878
Poland GA Vaccines against avian influenza - a race against time. N Engl J Med 2006; 354:1411 PMID: https://www.ncbi.nlm.nih.gov/pubmed/16571885
↑ Bresson JL, Perronne C, Launay O, Gerdil C, Saville M, Wood J, Hoschler K, Zambon MC. Safety and immunogenicity of an inactivated split-virion influenza A/Vietnam/1194/2004 (H5N1) vaccine: phase I randomised trial. Lancet. 2006 May 20;367(9523):1657-64. PMID: https://www.ncbi.nlm.nih.gov/pubmed/16714186
↑ FDA advisory panel backs prototype Glaxo bird flu virus Nov 14 2012 (Reuters) http://www.reuters.com/article/2012/11/14/glaxo-birdflu-vaccine-idUSL1E8MEJ8U20121114
↑ FDA News Release: Nov. 22, 2013 FDA approves first adjuvanted vaccine for prevention of H5N1 avian influenza. http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm376444.htm
↑ Brooks M FDA Approves Novel Pandemic Influenza Vaccine. Medscape - Feb 03, 2020. https://www.medscape.com/viewarticle/924729