cytochrome P450 2A6 (cytochrome P450 2A3, cytochrome P450 2B, cytochrome P450(I), coumarin 7-hydroxylase, CYP2A6, CYP2A3)

Introduction

formerly cytochrome P450 2A3

Function

• coumarin 7-hydroxylase activity
• hydroxylation of the anti-cancer drugs
  • cyclophosphamide
  • ifosphamide
  • metabolic activation of aflatoxin
  • nicotine C-oxidase
• inducers
  • phenobarbital
  • dexamethasone
• substrates
  • cyclophosphamide
  • ifosphamide
  • aflatoxin
  • nicotine

Compartment

• endoplasmic reticulum membrane
• peripheral membrane protein, microsome membrane

Expression

• expressed in liver
• induced by: phenobarbital, dexamethasone

Polymorphism

CYP2A6*2 allele causes switching from 7-hydroxylation to 3-hydroxylation of coumarin.

More general terms

• cytochrome P450 2A (CYP2A)

Database

• UniProt: http://www.uniprot.org/uniprot/P11509.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1548
• OMIM: https://mirror.omim.org/entry/122720
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1548