immunoglobulin gamma-3 chain (Ig-gamma 3); heavy chain disease protein

Structure

• dimer linked by 12 disulfide bonds
• the hinge region in gamma-3 chains is about four times as long as in other gamma chains & contains three identical 15-residue segments preceded by a similar 17-residue segment (12-28)
• extra interchain disulfide bond at position 7 in addition to the 11 normally present in the hinge region

Compartment

secreted

Pathology

• see heavy chain disease
• disease protein WIS is lacking most of the V region & all of the CH1 region
• disease protein ZUC lack most of the V region, all of the CH1 region, & part of the hinge compared with normal gamma-3 heavy chains
• disease protein OMM may represent an allelic form or another gamma chain subclass

More general terms

• immunoglobulin gamma chain (Ig-gamma)

Additional terms

• immunoglobulin-G (IgG, Cuvitru)

Database

• OMIM: https://mirror.omim.org/entry/147120
• UniProt: http://www.uniprot.org/uniprot/P01860.html