isocitrate

Introduction

Biochemistyr:

• an intermediate metabolite in the citric acid cycle.
• formed from citrate by aconitase-mt
  • enzyme: aconitase-mt
  • substrate: citrate
  • product: isocitrate
• metabolized to alpha-ketoglutarate by isocitrate dehydrogenase in a reaction that feeds electrons into the electron transport chain via NADH
  • enzyme: isocitrate dehydrogenase
  • substrates: isocitrate + NAD+
  • products: alpha-ketoglutarate + NADH + CO2

* see citric acid cycle for role of isocitrate in citric acid cycle

More general terms

• carboxylate
• intermediary metabolite

Additional terms

• citric acid cycle, Krebs cycle or tricarboxylic acid [TCA] cycle

Database

• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=1198
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=439238