aconitate hydratase, mitochondrial (citrate hydro-lyase, aconitase-2, ACO2)

Function

• carbohydrate metabolism; tricarboxylic acid cycle
• converts citrate to isocitrate via cis-aconitate
• inhibited by chloroacetate

citrate <--> isocitrate

Cofactor:

• binds 1 4Fe-4S cluster per subunit. binding of a 3Fe-4S cluster leads to an inactive enzyme (putative)

Structure

• monomer (putative)
• belongs to the aconitase/IPM isomerase family

Compartment

mitochondrial matrix (putative)

More general terms

• aconitase, aconitate-hydratase or citrate hydrolyase
• citric acid cycle enzyme

Additional terms

• citric acid cycle, Krebs cycle or tricarboxylic acid [TCA] cycle

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:50;
• OMIM: https://mirror.omim.org/entry/100850
• UniProt: http://www.uniprot.org/uniprot/Q99798.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=50