equol
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Introduction
An isoflavone (phytoestrogen)
Biochemistry
- synthesized from daidzein by Asaccharobacter celatus
- other gut bacteria can also synthesize equol
Pharmacology
- metabolite of soy produced by gut bacteria
- equol production linked to 50% lower white matter lesion burden
Physiology
Clinical manifestations
- equol is linked to improved brain function in older adults[3]
- equol is associated with executive function
- some studies have found that consumption of soy foods in the diet has no effect on cognitive function[4]
Notes
- equol is available as a dietary supplement*
* no randomized clinical trials support benefit
More general terms
More specific terms
References
- ↑ Merck Index, I2th ed, Merck & Co, Rahway NJ, 1996 # 3677
- ↑ George J Soy Metabolite Tied to Dementia Risk Factor - Equol production linked to lower white matter lesion levels. MedPage Today October 22, 2020 https://www.medpagetoday.com/neurology/dementia/89271
Sekikawa A, et al Associations of equol-producing status with white matter lesion and amyloid-beta deposition in cognitively normal elderly Japanese. Alzheimer's Dement 2020 PMID: https://www.ncbi.nlm.nih.gov/pubmed/33117881 Free PMC article. - ↑ 3.0 3.1 Nuzum N Gut microbiome: Meet Asaccharobacter celatus - the brain health bug Medical Xpress. March 2024 https://www.msn.com/en-us/health/other/gut-microbiome-meet-asaccharobacter-celatus-the-brain-health-bug/ar-BB1i6Keb
Nuzum N Gut microbiome: meet Asaccharobacter celatus - the brain health bug. The Conversation. Feb 9, 2024 https://theconversation.com/gut-microbiome-meet-asaccharobacter-celatus-the-brain-health-bug-208344 - ↑ 4.0 4.1 Kreijkamp-Kaspers S, Kok L, Grobbee DE et al Dietary Phytoestrogen Intake and Cognitive Function in Older Women. J Gerontol A Biol Sci Med Sci. 2007 May;62(5):556-62 PMID: https://www.ncbi.nlm.nih.gov/pubmed/17522362