cholesterol ozonolysis metabolite 2

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[1]

Introduction

Ozonolysis product of cholesterol. Occurs in human brain during inflammation. The aldehyde moiety covalently binds A-beta accelerating amyloidogenesis.

More general terms

References

  1. ↑ Zhang, Q et al, Metabolite-initiated protein misfolding may trigger Alzheimer's disease, Proc. Natl. Acad. Sci. USA, 10.1073/pnas.0400924101 http://www.pnas.org/cgi/content/abstract/0400924101
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