xanthohumol
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Introduction
Prenylatated flavonoid found in hops.
Mechanism of action
- antiproliferative[1]
- induces apoptosis[5][8]
- inhibits angiogenesis
- inhibits NF-kappa-B activation in prostate epithelial cells[3]
- inhibits Akt expression
- inhibits prostatic hypertrophy
- inhibits aromatase activity
- induces quinine reductase[7]
More general terms
References
- ↑ 1.0 1.1 Delmulle L, Bellahcene A, Dhooge W, Comhaire F, Roelens F, Huvaere K, Heyerick A, Castronovo V, De Keukeleire D. Anti-proliferative properties of prenylated flavonoids from hops (Humulus lupulus L.) in human prostate cancer cell lines. Phytomedicine. 2006 May 4; [Epub ahead of print] PMID: https://www.ncbi.nlm.nih.gov/pubmed/16678392
- ↑ Monteiro R, Becker H, Azevedo I, Calhau C. Effect of hop (Humulus lupulus L.) flavonoids on aromatase (estrogen synthase) activity. J Agric Food Chem. 2006 Apr 19;54(8):2938-43. PMID: https://www.ncbi.nlm.nih.gov/pubmed/16608212
- ↑ 3.0 3.1 Colgate EC, Miranda CL, Stevens JF, Bray TM, Ho E. Xanthohumol, a prenylflavonoid derived from hops induces apoptosis and inhibits NF-kappaB activation in prostate epithelial cells. Cancer Lett. 2006 Mar 22; [Epub ahead of print] PMID: https://www.ncbi.nlm.nih.gov/pubmed/16563612
- ↑ Albini A, Dell'Eva R, Vene R, Ferrari N, Buhler DR, Noonan DM, Fassina G. Mechanisms of the antiangiogenic activity by the hop flavonoid xanthohumol: NF-kappaB and Akt as targets. FASEB J. 2006 Mar;20(3):527-9. Epub 2005 Dec 30. PMID: https://www.ncbi.nlm.nih.gov/pubmed/16403733
- ↑ 5.0 5.1 Lust S, Vanhoecke B, Janssens A, Philippe J, Bracke M, Offner F. Xanthohumol kills B-chronic lymphocytic leukemia cells by an apoptotic mechanism. Mol Nutr Food Res. 2005 Sep;49(9):844-50. PMID: https://www.ncbi.nlm.nih.gov/pubmed/16144030
- ↑ Nozawa H. Xanthohumol, the chalcone from beer hops (Humulus lupulus L.), is the ligand for farnesoid X receptor and ameliorates lipid and glucose metabolism in KK-A(y) mice. Biochem Biophys Res Commun. 2005 Oct 28;336(3):754-61. PMID: https://www.ncbi.nlm.nih.gov/pubmed/16140264
- ↑ 7.0 7.1 Dietz BM, Kang YH, Liu G, Eggler AL, Yao P, Chadwick LR, Pauli GF, Farnsworth NR, Mesecar AD, van Breemen RB, Bolton JL. Xanthohumol isolated from Humulus lupulus Inhibits menadione- induced DNA damage through induction of quinone reductase. Chem Res Toxicol. 2005 Aug;18(8):1296-305. PMID: https://www.ncbi.nlm.nih.gov/pubmed/16097803
- ↑ 8.0 8.1 Pan L, Becker H, Gerhauser C. Xanthohumol induces apoptosis in cultured 40-16 human colon cancer cells by activation of the death receptor- and mitochondrial pathway. Mol Nutr Food Res. 2005 Sep;49(9):837-43. PMID: https://www.ncbi.nlm.nih.gov/pubmed/15995977