xanthohumol

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Introduction

Prenylatated flavonoid found in hops.

Mechanism of action

More general terms

References

  1. 1.0 1.1 Delmulle L, Bellahcene A, Dhooge W, Comhaire F, Roelens F, Huvaere K, Heyerick A, Castronovo V, De Keukeleire D. Anti-proliferative properties of prenylated flavonoids from hops (Humulus lupulus L.) in human prostate cancer cell lines. Phytomedicine. 2006 May 4; [Epub ahead of print] PMID: https://www.ncbi.nlm.nih.gov/pubmed/16678392
  2. Monteiro R, Becker H, Azevedo I, Calhau C. Effect of hop (Humulus lupulus L.) flavonoids on aromatase (estrogen synthase) activity. J Agric Food Chem. 2006 Apr 19;54(8):2938-43. PMID: https://www.ncbi.nlm.nih.gov/pubmed/16608212
  3. 3.0 3.1 Colgate EC, Miranda CL, Stevens JF, Bray TM, Ho E. Xanthohumol, a prenylflavonoid derived from hops induces apoptosis and inhibits NF-kappaB activation in prostate epithelial cells. Cancer Lett. 2006 Mar 22; [Epub ahead of print] PMID: https://www.ncbi.nlm.nih.gov/pubmed/16563612
  4. Albini A, Dell'Eva R, Vene R, Ferrari N, Buhler DR, Noonan DM, Fassina G. Mechanisms of the antiangiogenic activity by the hop flavonoid xanthohumol: NF-kappaB and Akt as targets. FASEB J. 2006 Mar;20(3):527-9. Epub 2005 Dec 30. PMID: https://www.ncbi.nlm.nih.gov/pubmed/16403733
  5. 5.0 5.1 Lust S, Vanhoecke B, Janssens A, Philippe J, Bracke M, Offner F. Xanthohumol kills B-chronic lymphocytic leukemia cells by an apoptotic mechanism. Mol Nutr Food Res. 2005 Sep;49(9):844-50. PMID: https://www.ncbi.nlm.nih.gov/pubmed/16144030
  6. Nozawa H. Xanthohumol, the chalcone from beer hops (Humulus lupulus L.), is the ligand for farnesoid X receptor and ameliorates lipid and glucose metabolism in KK-A(y) mice. Biochem Biophys Res Commun. 2005 Oct 28;336(3):754-61. PMID: https://www.ncbi.nlm.nih.gov/pubmed/16140264
  7. 7.0 7.1 Dietz BM, Kang YH, Liu G, Eggler AL, Yao P, Chadwick LR, Pauli GF, Farnsworth NR, Mesecar AD, van Breemen RB, Bolton JL. Xanthohumol isolated from Humulus lupulus Inhibits menadione- induced DNA damage through induction of quinone reductase. Chem Res Toxicol. 2005 Aug;18(8):1296-305. PMID: https://www.ncbi.nlm.nih.gov/pubmed/16097803
  8. 8.0 8.1 Pan L, Becker H, Gerhauser C. Xanthohumol induces apoptosis in cultured 40-16 human colon cancer cells by activation of the death receptor- and mitochondrial pathway. Mol Nutr Food Res. 2005 Sep;49(9):837-43. PMID: https://www.ncbi.nlm.nih.gov/pubmed/15995977

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