cytochrome P450 19A1 (aromatase, estrogen synthetase, CYP19A1)
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Function
- catalyzes conversion of androstenedione & testosterone to estrone & estradiol, the rate limiting step in estrogen synthesis in peripheral tissues
Structure
belongs to the cytochrome P450 family
Compartment
membrane, peripheral membrane
Expression
- expressed in brain, gonads, placenta
- granulosa cells within the ovary contain large amounts of aromatase
Pathology
- defects in CYP19A1 are the cause of aromatase deficiency
More general terms
Additional terms
References
- ↑ OMIM https://mirror.omim.org/entry/107910
- ↑ Kaiser Permanente Northern California Regional Drug Formulary, Update 9/99
- ↑ Medical Knowledge Self Assessment Program (MKSAP) 11, American College of Physicians, Philadelphia 1998
- ↑ Wikipedia; Aromatase entry http://en.wikipedia.org/wiki/Aromatase
- ↑ GeneReviews https://www.genecards.org/cgi-bin/carddisp.pl?gene=CYP19A1
- ↑ UniProt http://www.uniprot.org/uniprot/P11511.html