diazoxide (Hyperstat, Hypertonalum, Proglycem)

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Introduction

Tradename: Hyperstat.

Indications

Contraindications

Caution:

pregnancy category = c

safety in lactation = -

Dosage

  • 1-3 mg/kg up to 150 mg IV every 5-15 min
  • 50-100 mg IV every 5-10 min until satisfactory blood pressure

Pharmacokinetics

  • onset of action: 3-5 min

elimination via liver

1/2life = 17-31 min

Adverse effects

Mechanism of action

More general terms

References

  1. The Pharmacological Basis of Therapeutics, 9th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1996
  2. 2.0 2.1 2.2 Deprecated Reference
  3. 3.0 3.1 FDA Safety Alert. July 16, 2015 Proglycem (diazoxide): Drug Safety Communication - Reports of Pulmonary Hypertension in Infants and Newborns. http://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm455125.htm

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