lysergic acid diethylamide (LSD, Lysergide, Lysergamid)

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Indications

Clinical manifestations

Dosage

  • doses as low as 20-25 ug can produce effects

Pharmacokinetics

  • onset of psychological effects occurs 30-60 minutes after ingestion
  • peak effects in ~5 hours
  • effects last ~12 hours

1/2life = 3.5-4 hours

protein binding = 90 %

Adverse effects

Drug interactions

Laboratory

Mechanism of action

Management

More general terms

Additional terms

References

  1. The Pharmacological Basis of Therapeutics, 8th ed. Gilman et al, eds. Permagon Press/McGraw Hill pg 941
  2. Clinical Guide to Laboratory Tests, NW Tietz (ed) 3rd ed, WB Saunders, Philadelpha 1995
  3. 3.0 3.1 Preller KH, Herdener M, Pokorny T et al The Fabric of Meaning and Subjective Effects in LSD-Induced States Depend on Serotonin 2A Receptor Activation. Current Biology Jan 2017 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/28132813 <Internet> http://www.cell.com/current-biology/fulltext/S0960-9822(16)31510-X
  4. 4.0 4.1 4.2 4.3 Sinert RO Fast Five Quiz: Psilocybin and Other Hallucinogenic Drugs. Medscape. September 07, 2021 https://reference.medscape.com/viewarticle/957547
  5. Rega PP, Thornton SL LSD Toxicity Medscape. Jan 4, 2019 https://emedicine.medscape.com/article/1011615-overview#showall
  6. 6.0 6.1 NEJM Knowledge+ Psychiatry

Database