dicloxacillin (Dynapen, Pathocil)

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Introduction

Tradenames: Dynapen, Pathocil. 2nd generation penicillin.

Indications

Contraindications

pregnancy category = b

safety in lactation = ?

Dosage

  • should be taken on an empty stomach
  • 125-500 mg PO QID
  • pediatrics: 12-25 mg/kg/day divided QID

Tabs: (Capsule) 125, 250, 500 mg.

Elixir: 62.5 mg/5 mL (80, 100, 200 mL).

Pharmacokinetics

elimination via kidney

1/2life = 1 hour

Adverse effects

Drug interactions

Mechanism of action

More general terms

References

  1. The Pharmacological Basis of Therapeutics, 9th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1996
  2. Medical Knowledge Self Assessment Program (MKSAP) 11, American College of Physicians, Philadelphia 1998
  3. Kaiser Permanente Northern California Regional Drug Formulary, 1998
  4. Drug Information & Medication Formulary, Veterans Affairs, Central California Health Care System, 1st ed., Ravnan et al eds, 1998
  5. Deprecated Reference
  6. Jump up to: 6.0 6.1 Pottegard A, Henriksen DP, Madsen KG et al Change in International Normalized Ratio Among Patients Treated With Dicloxacillin and Vitamin K Antagonists. JAMA. 2015;314(3):296-297. <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/26197191 <Internet> http://jama.jamanetwork.com/article.aspx?articleid=2397825

Database