methenamine (Mandelamine, Hiprex, Urex)

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Introduction

Tradenames: Mandelamine, Hiprex, Urex.

Indications

Contraindications

pregnancy category = c

safety in lactation = +

Dosage

Tablet: as hippurate (Hiprex, Urex) 1 g

Tablet: as mandelate (Mandelamine) 500 mg, 1 g.

Pharmacokinetics

  • 10-20% metabolized by the liver
  • 1/2life is 3-6 hours
  • 90% eliminated in the urine
  • decreased effects are observed in patients with non-acidic urine

elimination via kidney

elimination via liver

Antimicrobial activity

Most strains of Proteus, Pseudomonas & Enterobacter are resistant.

Adverse effects

Drug interactions

Mechanism of action

More general terms

Component of

References

  1. Drug Information & Medication Formulary, Veterans Affairs, Central California Health Care System, 1st ed., Ravnan et al eds, 1998
  2. The Pharmacological Basis of Therapeutics, 9th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1996
  3. Kaiser Permanente Northern California Regional Drug Formulary, 1998
  4. 4.0 4.1 4.2 Harding C, Forbes R, Currer S et al. Alternative to prophylactic antibiotics for the treatment of recurrent urinary tract infections in women: Multicentre, open label, randomised, non-inferiority trial. BMJ 2022 Mar 9; 376:e068229. PMID: https://www.ncbi.nlm.nih.gov/pubmed/35264408 Free article

Database