dienestrol (DV cream, Cycladiene)
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Indications
- symptomatic management of menopause symptoms
Dosage
- vaginal:
- 1-2 applications/day for 2 weeks
- 1 application/day for 2 additional weeks
- maintenance: 1 application 1-3 times/week for 3 weeks each month
Vaginal cream (with applicator): 0.01% (30 g)
Pharmacokinetics
- topical vaginal application is associated with extensive absorption into the systemic circulation
Adverse effects
- not common (1-10%)
- anorexia, abdominal cramping, peripheral edema, breast tenderness, breast enlargement
- uncommon (< 1%)
- hypertension, thromboembolism, stroke, myocardial infarction, migraine, dizziness, anxiety, depression, headache, chloasma, melasma, rash, decreased glucose tolerance, alteration in menses flow, nausea, GI distress, increased triglycerides, increased LDL cholesterol, cholestatic jaundice, increased susceptibility to Candida infection