diethylpropion (Amfepramone, Frekentine, Moderatan, Dobesin)

Introduction

DEA-controlled substance: class 4.

Indications

• appetite suppressant

Dosage

• 25 mg PO before meals
• 75 mg PO QAM (slow release)
• 25-75 mg PO QD

Pharmacokinetics

• metabolized in liver to largely inactive metabolites
• metabolites excreted by the kidney

elimination via liver

elimination via kidney

1/2life = 4-6 hours

Adverse effects

• insomnia
• agitation
• nervousness
• hyperthermia
• hyperventilation
• hypertension
• convulsions

• drug adverse effects of analeptics
• drug adverse effects of psychotropic agents
• drug adverse effects of sympathomimetic(s)

Interferences

• may cause false positives in immunoassays for amphetamines in urine

Mechanism of action

• CNS stimulants
• appetite suppressant

More general terms

• adrenergic neuron stimulant
• analeptic (CNS stimulant)
• amine
• aromatic compound

Database

• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=7029
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=91442