bithionol (Bithin)

Introduction

Chlorinated phenol. Investigational Drug in USA.

Indications

• fascioliasis
• paragonimiasis

Dosage

30-50 mg/kg PO in daily doses for 10-15 doses after meals

Pharmacokinetics

• animal studies suggest hepatic metabolism

Adverse effects

• gastrointestinal symptoms
  • nausea/vomiting
  • diarrhea
  • abdominal pain
• skin rashes
• photosensitivity reactions
• angioedema
• headache
• dizziness
• hypotension
• hepatitis (uncommon)
• leukopenia (rare)

Mechanism of action

• appetite suppressant

More general terms

• antihelmintic
• phenol

Database

• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=2406