dutasteride (Avodart)

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Indications

Contraindications

Dosage

0.5 mg PO QD with or without food

Pharmacokinetics

Adverse effects

Drug interactions

Mechanism of action

Clinical trials

Notes

Manufacturer: GalaxoSmithKline

More general terms

Component of

References

  1. Prescriber's Letter 9(2):S1 2002
  2. 2.0 2.1 Prescriber's Letter 9(12):70 2002
  3. 3.0 3.1 Prescriber's Letter 10(7):37 2003
  4. 4.0 4.1 4.2 Andriole GL et al Effect of Dutasteride on the Risk of Prostate Cancer New Eng J Med 2010 362:1192-1202 PMID: https://www.ncbi.nlm.nih.gov/pubmed/20357281
    Walsh PC Chemoprevention of Prostate Cancer New Eng J Med 2010 362:1237 PMID: https://www.ncbi.nlm.nih.gov/pubmed/20357287
  5. 5.0 5.1 Fleshner NE et al. Dutasteride in localised prostate cancer management: The REDEEM randomised, double-blind, placebo-controlled trial. Lancet 2012 Jan 24 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/22277570 <Internet> http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(11)61619-X/fulltext
    Parker C. What (if anything) to do about low-risk prostate cancer. Lancet 2012 Jan 24; <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/22277569 <Internet> http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(12)60066-X/fulltext
  6. 6.0 6.1 Prescriber's Letter 20(3): 2013 Persistent Sexual Dysfunction with Finasteride and Dutasteride Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=290308&pb=PRL (subscription needed) http://www.prescribersletter.com
  7. 7.0 7.1 Toren P et al Effect of dutasteride on clinical progression of benign prostatic hyperplasia in asymptomatic men with enlarged prostate: a post hoc analysis of the REDUCE study. BMJ 2013;346:f2109 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/23587564 <Internet> http://www.bmj.com/content/346/bmj.f2109
  8. 8.0 8.1 Geriatric Review Syllabus, 8th edition (GRS8) Durso SC and Sullivan GN (eds) American Geriatrics Society, 2013
    Geriatric Review Syllabus, 11th edition (GRS11) Harper GM, Lyons WL, Potter JF (eds) American Geriatrics Society, 2022
  9. 9.0 9.1 9.2 Nickel JC Comparison of clinical trials with finasteride and dutasteride. Rev Urol. 2004;6 Suppl 9:S31-9. PMID: https://www.ncbi.nlm.nih.gov/pubmed/16985923 Free PMC Article
  10. 10.0 10.1 Nickel JC, Gilling P, Tammela TL et al Comparison of dutasteride and finasteride for treating benign prostatic hyperplasia: the Enlarged Prostate International Comparator Study (EPICS). BJU Int. 2011 Aug;108(3):388-94. Epub 2011 Jun 1. PMID: https://www.ncbi.nlm.nih.gov/pubmed/21631695 Free Article
  11. 11.0 11.1 Gubelin Harcha W, Barboza Martinez J, Tsai TF et al A randomized, active- and placebo-controlled study of the efficacy and safety of different doses of dutasteride versus placebo and finasteride in the treatment of male subjects with androgenetic alopecia. J Am Acad Dermatol. 2014 Mar;70(3):489-498.e3. Epub 2014 Jan 9. PMID: https://www.ncbi.nlm.nih.gov/pubmed/24411083
  12. 12.0 12.1 Medical Knowledge Self Assessment Program (MKSAP) 18, 19 American College of Physicians, Philadelphia 2018, 2022
  13. http://www.fda.gov/cder/consumerinfo/druginfo/avodart.htm
  14. http://www.avodart.com

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