3-oxo-5-alpha-steroid 4 dehydrogenase 1; steroid 5-alpha reductase 1; testosterone 5-alpha reductase 1; SR type 1 (SRD5A1, S5AR)

Function

• converts testosterone into 5-alpha-dihydrotestosterone & progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids
• role in sexual differentiation & androgen physiology
• optimally active at alkaline pHs

Structure

belongs to the steroid 5-alpha reductase family

Compartment

• microsome membrane
• endoplasmic reticulum membrane

Expression

• liver & prostate (at a low level)
• expression is regulated by androgens such as testosterone

More general terms

• 3-oxo-5-alpha-steroid 4 dehydrogenase

Database

• UniProt: http://www.uniprot.org/uniprot/P18405.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6715
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6715
• OMIM: https://mirror.omim.org/entry/184753