arachidonate cyclooxygenase cascade

Biochemistry

• AA CO cascade 1
  • enzyme: prostaglandin synthase
  • substrate: arachidonate + 2 O2
  • product: PGG2
• AA CO cascade 2
  • enzyme: prostaglandinsynthase
  • substrate: PGG2 + 2 GSH
  • product: PGH2 + GSSG
• AA CO cascade 3
  • enzyme: isomerase
  • substrate: PGH2
  • product: PGD2
• AA CO cascade 4
  • enzyme: isomerase
  • substrate: PGH2
  • product: PGE2
• AA CO cascade 5
  • enzyme: isomerase
  • substrate: PGH2
  • product: PGF2-alpha
• AA CO cascade 6
  • enzyme: isomerase
  • substrate: PGH2
  • product: PGI2
• AA CO cascade 7
  • enzyme: thromboxane-A-synthase
  • substrate: PGH2
  • product: thromboxane-A2
• AA CO cascade 8
  • substrate: thromboxane-A2
  • product: thromboxane-B2)
• AA CO cascade 9
  • enzyme: isomerase
  • substrate: PGH2
  • product: PGA2

* see figure

More general terms

• cyclooxygenase cascade
• arachidonate cascade

Additional terms

• arachidonate; arachidonic acid [C20:4w6, ARA]
• cyclooxygenase (prostaglandin endoperoxide synthase, COX)