eicosapentaenoate lipoxygenase cascade

Biochemistry

EPA LPO cascade 1
- enzyme: 5-lipoxygenase
- sustrate: eicosapentaenoate + O2
- product: 5-HPEPE
EPA LPO cascade 2
- enzyme: 12-lipoxygenase
- sustrate: eicosapentaenoate + O2
- product: 12-HPEPE)
EPA LPO cascade 3
- enzyme: 15-lipoxygenase
- sustrate: eicosapentaenoate + O2
- product: 15-HPEPE)
EPA LPO cascade 4
- sustrate: 5-HPEPE
- product: 5-HEPE)
EPA LPO cascade 5
- sustrate: 12-HPEPE
- product: 12-HEPE)
EPA LPO cascade 6
- sustrate: 15-HPEPE
- product: 15-HEPE)
EPA LPO cascade 7
- enzyme: LTA synthase
- sustrate: 5-HPEPE
- product: LTA5
EPA LPO cascade 8
- enzyme: leukotriene-B synthase
- sustrate: LTA5
- product: LTB5
EPA LPO cascade 9
- enzyme: enzyme
- sustrate: LTA5 + GSH
- product: LTC5
EPA LPO cascade 10
- enzyme: enzyme
- sustrate: LTC5
- product: LTD5
EPA LPO cascade 11
- enzyme: enzyme
- sustrate: LTD5
- product: LTE5
EPA LPO cascade 12
- enzyme: enzyme
- sustrate: LTC5
- product: LTF5 ;