Leukotriene A4 hydrolase; Leukotriene B4 synthase; LTA-4 hydrolase; LTB4 synthase (LTA4H)

Function

• hydrolyzes an epoxide moiety of leukotriene A4 (LTA-4) to form leukotriene B4 (LTB-4)
• the enzyme also has some peptidase activity
• lipid metabolism; leukotriene B4 biosynthesis

Cofactor: binds 1 Zn+2 per subunit

Structure

• monomer
• belongs to the peptidase M1 family

Compartment

cytoplasm

Alternative splicing

named isoforms=2

More general terms

• zinc metalloprotease

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4048
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4048
• OMIM: https://mirror.omim.org/entry/151570
• UniProt: http://www.uniprot.org/uniprot/P09960.html