eicosapentaenoate cyclooxygenase cascade

Biochemistry

• EPA CO cascade 1
  • enzyme: prostaglandin_synthase
  • sustrate: eicosapentaenoate + 2 O2
  • product: PGG3
• EPA CO cascade 2
  • enzyme: prostaglandin_synthase
  • sustrate: PGG3 + 2 GSH
  • product: PGH3 + GSSG
• EPA CO cascade 3
  • enzyme: isomerase
  • sustrate: PGH3
  • product: PGD3
• EPA CO cascade 4
  • enzyme: isomerase
  • sustrate: PGH3
  • product: PGE3
• EPA CO cascade 5
  • enzyme: isomerase
  • sustrate: PGH3
  • product: PGF3-alpha
• EPA CO cascade 6
  • enzyme: isomerase
  • sustrate: PGH3
  • product: PGI3
• EPA CO cascade 7
  • enzyme: thromboxane-A synthase
  • sustrate: PGH3
  • product: thromboxane-A3
• EPA CO cascade 8
  • sustrate: thromboxane-A3
  • product: thromboxane-B3)
• EPA CO cascade 9
  • enzyme: isomerase
  • sustrate: PGH3
  • product: PROSTAGLANDIN-A3

* see figure

More general terms

• cyclooxygenase cascade
• eicosapentaenoate cascade

Additional terms

• 5,8,11,14,17-eicosapentaenoic acid [C20:5w3]
• cyclooxygenase (prostaglandin endoperoxide synthase, COX)